What 'graded evidence' actually means
The four-tier system behind every claim on PEPHORMIA - and why honesty about limits is the whole point.
Most of the internet sells peptides on the strongest-sounding claim it can find. We do the opposite: we start from the peer-reviewed record and tag each finding by how strong it really is. Four tiers, one honesty line on every claim.
The four tiers
- Strong — replicated human trials. The finding has held up more than once in people.
- Human — clinical, but limited in scale: a single trial, a small sample, or a narrow population.
- Weak — a small or mixed signal. Preliminary; treat with caution.
- Mechanistic — preclinical or in-vitro only. A story about how something might work, not proof that it does in a human.
Why the honesty line matters
Alongside every claim we state what the evidence doesn't show. That single sentence is the discipline the rest of the market skips — because a lab-dish result dressed up as a human outcome sells better. It also happens to be wrong. Grading evidence honestly is slower and less flattering, and it is the entire product.
You'll see the four-tier box across the whole platform: on the Learn hubs, in the Library reviews, and throughout the blog.