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Skin & hair

The one bucket you can also shop — 50 years of GHK-Cu research, read honestly.

GHK-Cu · Matrixyl-class

Our writeups

2
evidence review · Free

Copper Peptides (GHK-Cu), Decoded

A nine-page cited review of GHK-Cu — discovery, the four-pathway mechanism, the human skin data, the delivery problem, and an honest map of proven vs mechanistic.

Subscribe to unlock → article · 12 min · 13 sources

Copper peptides: what the evidence actually shows

GHK-Cu has 50 years of research and one delivery problem. The mechanism, the human data, and the honest limits — graded.

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Primary papers

4
Growth-modulating plasma tripeptide facilitates copper uptake into cells
Pickart L, et al. Nature 1980;288:715–717
Strong↗
Stimulation of collagen synthesis by the GHK-Cu complex
Maquart FX, et al. FEBS Lett 1988;238(2):343–346
Mechanistic↗
Regenerative and protective actions of GHK-Cu — new gene data
Pickart L, Margolina A. Int J Mol Sci 2018;19(7):1987
Mechanistic↗
Copper peptides in regenerative aesthetic dermatology
Sarbaziha R, et al. Dermatological Reviews 2026
Doesn't show: Review; verify individual primary citations at source before relying on them.
Human↗

Educational purpose only. PEPHORMIA aggregates and grades published scientific literature. Nothing here is medical advice, diagnosis, or treatment, and nothing here is a recommendation to obtain, dose, or use any compound. We do not sell, supply, or facilitate access to prescription medicines or injectable peptides. Products offered are cosmetic-grade topical formulations described by appearance only. Peptide and hormone use carries real risks — consult a qualified healthcare professional before any decision. Statements have not been evaluated by the TGA or FDA.